Virginia
There are tons of Hugheses in Virginia - and lots in Chalkley’s Chronicles - but I haven’t separated them out yet. It always helps to have an idea what you’re looking for. . . Henry and Elizabeth Hughes Deweese married in Philadelphia in 1768 and were in Virginia ~1772 - 1786.

These are the ones I have found so far, and the dates they are first mentioned:
        1746 - Edward Hughes
        1749 - Rosamond Hughes
        1751 - Even Hughes
        1760 - James Hughes
        1761 - James Hughes, John Hughes
        1762 - Jno Hughes, James Hughes
        1767 - James Hughes, deceased - wife and daughter Euphemia, daughter by 1st wife Margaret Kennedy / Saml Hughes
        1773 - Barnibas Hughes
        1774 - Thos Hughes
        1777 - Miss Betsy Hughes (Greenbrier)
        1778 - Wm Hughes
        1799 - Uphemia Hughes’s will - mother Euphemia Hughes, Euphemia Hughes Bickle, nieces Mary Owen and Margaret Bickle
        1814 - Moses Hughes, Elizabeth Hughes

Chalkley's Chronicles is available online, and using the "find on this page" feature, you can search for whatever name you are interested in - it's pretty tedious because there are a lot of pages, but what riches!  Anyway, here are the actual entries from Chalkley - the ones I found anyway.

These must be from the Court Order Books???
August 20, 1746
      (72) Valentine Sevear--Ordinary license Edward Hughes surety.
August 21, 1746.
      (81) Jury--John Moffet, William Bates, Thomas Stinson, Edward Hughes, etc
August 22, 1746.
      (88) Ewell vs. Briant--Verdict, "we find for defendant." Atty. filed errors in arrest of judgment--referred to next Court.  William Pickins, witness in above suit. (89) Edward Hughes, witness in above suit.
August 22, 1749.
      (151) Rosemond Hughs, a servant of Mathew Thompson, petitions for freedom dues

Will Book 1
Page 485.--27th October, 1751. James Scot's will. Of South Branch of Potomac. Sister, Sarah Scot. Two mares bought of Even Hughes. Sister, Phebe Scot; sister, Rachel Scot. Three cousins (nephews?), James, Joseph, and Jacob Scot (sons of Bro. John?). Two brothers, Adonijah Scot and David Scot. Brother, Benjamin Scot. Two brothers are infants. Teste: Joel Hornback, John Frazier. Codicil, horses left to Bro. John Scot's children to be taken by Benj. Scot until they are of age. Proved, 22d March, 1753, by John Frazier and Ridle Hyer, and Benj. Scot qualifies administrator with sureties Henry Lancisco, Peter Mauzie.

Will Book 2
Page 391.--28th May, 1760. Samuel Wilson's will, of Staunton--Wife, Martha, to educate the children; oldest daughter, Elizabeth Wilson; daughter, Martha. Executors, John and Thos, Wilson, and wife Martha, or any two. Teste: James Hughes, Robt. Reed. Wm. Preston. Proved, 19th August, 1760, by the witnesses. Thomas and Martha qualify, with Jno. and Robt. Wilson. Teste: H. Churchill.

Page 437.--12th January, 1760. Deed of apprenticeship--William Hays, son of Patrick Hays, binds himself to William Wilson, taylor, to be taught the said trade, service and occupation of a taylor for 18 years. Signed,
Patrick Hays, William Wilson. Teste: James Stevenson, James Hughes, Wm Lusk.

Page 438.--20th May, 1760. John Poage's bond (with David Stewart, James Hughes) as Assistant Surveyor.

Will Book 3
Page 9.--17th February, 1761. Phillip Persinger''s appraisement, by Wm. Preston, Ro. Reed, James Hughes--Current money.

Page 28.--28th June, 1758. Peter Moser's estate settlement, by Michael Mallow, allowed 19th May, 1761--To Cathron Moser, Jno. Hopkins, Danl.Love, James McDole, Jno. Wright, Fardrick Kestor, Jacob Harper, Andrew Arewen, Powl Shaver, Eaform Love, Nickles Hofman, Edward McGary.(2nd vendue held 8th November, 1758?) To Alex. Miller, James McGill, Jno. McCoy. (3d vendue held 3d October, 1760.) Credit by Patterkole money received on Peter Moser's account. From Jno. Madison, from George Caplinger, from Henry Carr, from Captain Cartley (Keartley), Capt. Abraham Smith (patterole money), from Captain Smith, for provender; from Captain Smith, on account of Wm. Wood; from Jno. Hogleer; from Capt. Ephraim Love, for provender and paterrole (patrol) money; from Capt. Smith, patterole money. Paid Jacob Rolman, paid Daniel Smith for clorking, paid Fredk. Opp for schooling, paid Fredk. Easter for salt and store goods, paid Johnson Hill for weaving, paid John Hughes, paid Stephen Conrad, the blacksmith.

Page 150.--24th February, 1762. James Leister's estate, appraised by Jno. Hughes, Sampson Mathews, Mathew Reed.

Page 156.--6th February, 1762.--James Litster's estate sold to, viz. James Ward, Geo. Wilson, Mathew Reed, Wm. Cabeen, Chas. Donnally, Ro. Armstrong, Edward Long, Pat. Cunningham, Andw. Greer, Thos. Fulton, Margt. Cameron, Jno. Stewart, Ro. Reed, Geo. Francisco, David Bell, Wm. Poage, Wm. Crow, Luke Bowyer, Abraham Thornton. Wm. Henderson, Jno. Buchanan, Thos. O'Neal, Alex. Gibson, Alex. Wright, Jno. Francis, James Simpson, Geo. Weaver, Philip Helveston, Jno. King, Geo. Anderson, Rev. Mr. Craige, Andw. Russell, Saml.Caldwell, Joseph Roberts, Jno. Gregory, Jno. Lucas, Mathew Clark, Jno.Anderson, Jr., James Robinson, Jacob Parsinger, Saml. Moore, Christopher Vinyard, Thos. Patterson, the Widow Bell, Ralph Gorrell, Jos. Russell, James Gilmore, Simon Robertson, James Hughes.

Page 193.--27th September, 1762. John Wright's will--To wife, Lidy; to eldest son, Abraham, 300 acres called Ball Hill; to second son, James, 175 acres patented in name of testator's father, James Wright, and 30 acres adjoining the Bald Hill part of the Bear Wallow; to child wife is big with, remainder of Bear Wallow tract; to daughters, Elizabeth, Mary, Sarah, Janet, Easter and Lydia Wright, tract called Perish Lines; to third son, Joshua, 170 acres; to farther son, John, infant. Executors, wife Lydia and Daniel Smith. Teste: Michael Warren, Jno. Hughes, Egniar Virden. Proved, 18th November, 1762, by Micliael Warren and Egniar Virden. Executors qualified, with Jno. Bowyer.

Page 487.--20th January, 1767. John Colley (Cawley), aged 20 years, deposes, that being in the presence and company of James Hughs, deceased, during the time of his last sickness in the dwelling house of the said James, he heard him say that should will and bequeath by his last testament all his substance that he was possessed of to his wife Euphemia during her natural life, except a house and lot to his daughter Euphemia, as also the wearing apparel of his first wife, mother of Margt. Kennedy, which he should give and bequeath to the said Margaret, together with her mother's riding saddle, and that this conversation was had with the said decedant James about two days before his _____, which happened on Thursday morning, the 18th inst, and further sayeth not. Randolph Lockhart, aged 30 years, deposes to same effect. Proved, 20th January, 1767. Administration granted widow Euphemia and Sampson Mathews.

Page 513.--24th January, 1767. James Hughes' estate appraised, by Robt. McClenachan, Wm. Crow, Robt. Reed, Walter Cunningham.

Will Book 4
Page 40.--24th August, 1767. Account of administration of estate of Col. John McNeill, recorded--Cash paid Wm. Duncan for board of servants under cure; to gold watch sold George Weedon. 1765, April 1st- - Cash paid Joseph Gamble for riding express for Col. McNeile to Dr. Jameson. July 4th--Cash paid in part of Farghagh Cambel's account. November 5th--Cash paid James Hughes the balance of Farghagh Camil account. Cash paid Hector McNeil. 1766, January 1st--Cash paid Mr. James Melvin. 1766, January 9th--To cash paid Wm. Lewis for 750 pounds flower for ye use of ye detachment Col. McNeil marched to Fort Pitt. July 2d- - Cash paid John Coke. Credits--1765, February, by 5 ounces, 3 pennyweights of gold, ú25.16.0.; by 35 dollars and 2 half johannos, ú14.13.9.; by 1 moidon, 6 Inglish shillings; by cash from Col. Bouquet, ú90.0.0.; by cash from Capt. Walter Cunningham, ú12.16.9.; by cash from John Mann. August 20th, by cash from Edward Long for blankets. 1766, May 22d, by cash from Wm. Hyde.

Page 71.--24th November, 1767. James Hughes' estate settlement, recorded--Paid for making cakes for funeral. 1767, February 11th, by received from Saml. Hughes; by received from Andrew Russell, Sr. March 30th, by received from Wm. Dunlap, Jr. March 30th, by received from John Verner. July 25th, by received from Andrew Russell, Jr. July 27th, by balance for nursing a child. July 29th, by Wm. Howard's account; by James Colton's account. September 28th, by Jeremiah Edward's account. Oct. 7th, by remainder Saml. Hughens' bill. Bills due the estate that are doubtful: John Craney's, James Hill's, John Lindsey's, Jno. McNulty's, Hector McNeil's, Robt. Adair's, Benj. Woods, Richd. Dunn, Saml. Cloyd, Jno. Lucases, James Shaw's.

Will Book 5
Page 143.--19th August, 1773. Recorded, viz: 1761--The estate of the late William Long, of Staunton, Dr.; paid Barnibas Hughes, Doctor Lyn, clothing Wm. Long nine years. 1760--Contra.

Page 230.--19th April, 1774. William Crawford's bond (with Pet.Hog, Thos. Hughes) as assistant surveyor.

Will Book 6
Page 16.--21st April, 1778. Recorded. David Cunningham's appraisement by James Ewing, Samuel McCutchan, Wm. Hughes.

Page 334.--29th August, 1777. List of those indebted to the estate of Roger North--Molly Mathews, Michael Diveyer, John Pans, Taylor, Edward Brayton, Mary Dillon, Wm. Collen, Carolina; Rev. Adam Smith, Margaret Mountfield, Hannah Sires, Robt. Jameson, Prince Edward; Andrew Cowen, Holstein; John Adkins, going to Carolina; William Loveley, Sally McGraw, servant to Dr. Watkins; James Bowyer (Taylor), John Anderson, Long Glead, Holstein; Joseph Love, Montgomery; Geo. Berry (son to Francis), James Anderson, son of John, M. River; John Henderson, son to David, So. River, dead; John Brown, son to Widow, N. Mtn.; David Steel (tailor), Wm. Jordan, So. River; Wm. Scott (taylor), John Welsh (tailor), Amos Perkins (blacksmith), Michael McEntosh, James Cooper, Forks of James; Mary Blackwood, married to McCrosky; _____ Crawford, brother to Patrick; Wm. Russell, Buchanan's Mill; Charles Philips, Adam Cribb, Eleanor Craig, M. River; Eleanor Dunn at Elijah McClenachans, Robert Patterson, No. Mountain; Nelly Keenan, James Berry, son to Francis, Holst.; John Woods, M. River; Andrew Anderson, son to John; Andrew Jenkins; Major Scott (dead), Mark Hatton, Andrew Campbell, son to John, So. River; Andrew Wilson, reedmaker; James Anderson, M. River; James Kelly (mason), John Cypher, James Brown (dead), John Votaw, Wm. McNab, No. Mountain; Joseph Right, M. River; James Armstrong, Holstein; Wm. Long, Warm Springs; Jean Rush, Evan Griffith, son of Abel, M. River; James Bott, Alex. Reed, Rockfish; Miss Betsey Hughes, Greenbrier; Henry Black, Dutchman; Hugh Divier. No. River; John Smith, son of Daniel, dead; Gasper Carner, Black's Gap; Daniel Meek, Calfpasture; Mary Cawfield, Jacob Kile, No. Mountain; Wm. Rogers. B. M.; John Campbell, No. River; James Edmonson, taylor; Chas. Syms, attorney at law; Nath. Bell Magruder, James Long, Mid. River; Richard Aldeman, Jno. Ehrhard, laberer; James McManis, Amherst; Jno. Todd, attorney at law; Thos. Bird, labourer; Abraham Savage, Thos. Jones, at the Office; Jacob Meckghew, Pr. Edward; Jno. Heany, Miss Jenny Lewis, Thomas' daughter, Jno. Hughson, Mason.

Will Book 9
Page 43.--11th November, 1799. Uphemia (X) Hughes' will, of Staunton--To mother, Euphemia Hughes; to Euphemin Hughes Bickle; to nieces, Mary Owens and Margaret Bickle. Executor, Jacob Kinney. Teste: W. Chambers, Wm. Forbes, Vincent Tapp. Proved, 27th January, 1800.
Executor qualifies.

Will Book 11
Page 398.--15th March, 1814. Jane Black's will, of South River--To son Samuel; daughter, Jane Alexander; daughter, Martha Black; daughters Margaret Price and Mary Black; daughter. Nancy Gillespee; son, James; sons, John and William. Executors, sons James and Samuel. Teste: Joseph Bell, Moses Hughes, Elizabeth Hughes, Elizabeth Long. Proved, 24th October, 1814. Samuel qualifies.

I just happened to copy this info as I was looking at the Deweeses:
Botetourt County
Botetourt County, Virginia, its men, 1770-1777 by Charles T. Burton [Troutville, Va. : C.T. Burton, 197-?]
This is a little confused. (or I am a little confused)
      Deweese, Cornelius      tax list of J Bowman    date may be 1775      s side of Roanoke
                      Henry           exempted men 1772 Henry Dooes - court order
                                          tax list of Philip Love    date may be 1773     Roanoke R -> Fincastle bord
                                          Delinquent list (whole county) 1774                          
                                          tax list of A Donnelley            1775                 Greenbrier R
                      John             tax list of unknown        date may be 1771       Lower New R
                                          tax list of unknown        date may be 1772       Sink Creek and New R
      Hugh/s Anthony            tax listof J VanBibber             1772                 Greenbrier R & waters
                  David               tax list of Robert Doak           1777                 Looney’s Creek?
                  Thomas            tax list of Benj Estill                1774                 Sink Hole, Ind Cr etc
                                          tax list of James Henderson    1775                  Greenbrier, Sink Hole, etc

Botetourt County, Virginia, its men, 1780-1786 by Charles T. Burton [Troutville, Va. : C.T. Burton, 197-?]

The back country was organized into military districts - that's what the number 4 is: Captain Wilson's company (until 1781) and then Captain Martin's. It was located in what is now Floyd County.  MD means "military district" and it indicates someone eligible for the 82 draft. The 500 refers to acres - and apparently it was listed only by last name, so Burton just assigned the number to the first "Deweese" on the list.

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Page last updated 21 March 2006